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Motor proteins cause movement by: (1) undergoing a conformational change, (2) harnessing energy from ATP, and (3) binding to the cytoskeleton.


A) Statements (1) , (2) , and (3) are correct.
B) Statements (1) and (2) are correct.
C) Statements (1) and (3) are correct.
D) Statements (2) and (3) are correct.

E) B) and D)
F) A) and B)

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If intermediate filaments were capable of dynamic instability, which of the following outcomes would be MOST likely?


A) Cell adhesion would be affected.
B) Cilia would be altered.
C) Chromosome segregation would be affected.
D) Microvilli would collapse.
E) It is not possible to determine the outcome from the information given.

F) A) and C)
G) A) and D)

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Which one of the following properly groups a cell junction with a cytoskeletal element and cell adhesion molecule?


A) desmosome, microtubule, integrin
B) desmosome, microfilament, integrin
C) tight junction, cadherin, intermediate filament
D) adherens junction, microfilament, cadherin

E) A) and B)
F) B) and C)

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What is the advantage of forcing materials to travel through cells instead of between cells?


A) Cells can control which materials are transported.
B) Exposure to toxins is limited.
C) Exposure to bacteria or viruses is limited.
D) All of these choices are correct.

E) All of the above
F) C) and D)

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Which one of the following statements about integrins is CORRECT?


A) Integrins indirectly connect microfilaments with the extracellular matrix.
B) There is a single type of integrin, capable of binding to multiple types of extracellular matrix proteins.
C) Integrins are the primary cell adhesion molecule in a desmosome.
D) Adjacent integrins create channels referred to as gap junctions.

E) All of the above
F) C) and D)

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Many scientists use a specific type of mouse cell to coat the surface of petri dishes. These cells form a layer on which other kinds of cellsoften of different speciescan adhere and grow. The mouse cells used to coat petri dishes are likely:


A) epidermal cells.
B) melanocytes.
C) hepatocytes.
D) fibroblasts.
E) microvilli.

F) A) and C)
G) A) and B)

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Evidence that cytoskeletal elements have ancient origins comes from the:


A) sequence similarities of cytoskeletal elements when comparing distantly related organisms.
B) presence of cytoskeletal elements in both eukaryotes and prokaryotes.
C) observation that both prokaryotes and eukaryotes use cytoskeletal elements to assist cell division.
D) ability to form functional hybrid microfilaments from actin monomers taken from distantly related organisms.
E) All of these choices are correct.

F) A) and E)
G) C) and D)

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Which of the following is associated with microtubules?


A) desmosomes
B) adherens junction
C) cilia and flagella

D) All of the above
E) A) and B)

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In many cells, the adhesion to the extracellular matrix through integrins causes the activation of kinases in the cytoplasm. This suggests that:


A) integrins promote the activation of signal-transduction pathways.
B) integrins are kinases.
C) extracellular matrix proteins are receptors and integrins are ligands.

D) None of the above
E) B) and C)

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Some cell junctions allow materials to pass between adjacent cells so that they work together as a unit.

A) True
B) False

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The extracellular matrix is particularly important for which type of tissue?


A) epithelial
B) muscle
C) connective
D) nervous

E) A) and B)
F) A) and C)

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Epithelial tissue is found:


A) on the outer surface of the body.
B) lining the gastrointestinal tract.
C) lining the lungs.
D) lining blood vessels.
E) All of these choices are correct.

F) A) and B)
G) All of the above

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Keratinocytes are pigment cells contained in the epidermis of skin.

A) True
B) False

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Myosin is a motor protein that associates with:


A) microfilaments.
B) microtubules.
C) intermediate filaments.
D) vimentin.

E) B) and D)
F) None of the above

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A researcher is assessing the expression of a certain protein in cells. This protein appears as a "web" in the cytoplasm of cells. The protein is likely a component of:


A) the cytoskeleton.
B) cell junctions.
C) the extracellular matrix.
D) of the basal lamina.
E) All of these choices are correct.

F) B) and C)
G) C) and D)

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If cells did not have actin, they would be unable to:


A) organize proteins across the cytoplasmic membrane.
B) maintain shape.
C) connect to neighboring cells.
D) All of these choices are correct.

E) A) and C)
F) All of the above

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A tissue is generally composed of several organs.

A) True
B) False

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Suppose that frog embryos are genetically manipulated so that the epidermal cells expressed both E-cadherin and N-cadherin on their cell surface. The neuronal tissue and epidermal tissues are collected from the embryos and treated as illustrated in Figure 10.12b. Which of the following would you predict would happen now that N-cadherin is also present on the surface of the epidermal cells? Suppose that frog embryos are genetically manipulated so that the epidermal cells expressed both E-cadherin and N-cadherin on their cell surface. The neuronal tissue and epidermal tissues are collected from the embryos and treated as illustrated in Figure 10.12b. Which of the following would you predict would happen now that N-cadherin is also present on the surface of the epidermal cells?   A) The genetically modified epidermal cells would adhere to each other and to neuronal cells. B) The genetically modified epidermal cells would adhere to neuronal cells and would no longer adhere to epidermal cells. C) The genetically modified epidermal cells would adhere to each other, and not to the neuronal cells, because they would still be epidermal cells regardless of the presence of an additional cell adhesion protein on their surface.


A) The genetically modified epidermal cells would adhere to each other and to neuronal cells.
B) The genetically modified epidermal cells would adhere to neuronal cells and would no longer adhere to epidermal cells.
C) The genetically modified epidermal cells would adhere to each other, and not to the neuronal cells, because they would still be epidermal cells regardless of the presence of an additional cell adhesion protein on their surface.

D) A) and B)
E) A) and C)

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Microtubules increase in length:


A) more quickly at one end than the other.
B) by growing outward from the centrosome.
C) in cycles, following rapid depolymerization.
D) if free tubulin dimers are available.
E) All of these choices are correct.

F) All of the above
G) B) and C)

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Which one of the following is NOT a cellular function associated with microtubules?


A) muscle contraction
B) chromosome segregation
C) organization of organelles
D) movement of cilia and flagella

E) All of the above
F) B) and C)

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